About Reviews KPV

What this site is

Reviews KPV is an independent editorial project that publishes summaries of the peer-reviewed research literature on KPV, the lysine-proline-valine tripeptide ^[4]. We are not a clinic. We do not employ clinicians, and we do not provide medical advice. We do not manufacture, sell, or distribute any product. Our work is editorial commentary on publicly available science.

The "reviews" in our name describes what we do with the literature — we read it, summarize it, and cite it — not a product we stock or evaluate for purchase. Every quantitative claim on this site is tied to a numbered source on our KPV references and citations page, and our editorial standard is to attribute each finding to the study that reported it.

How we read the evidence

We treat KPV as what the literature shows it to be: a melanocortin-derived anti-inflammatory tripeptide with a reproducible preclinical record in the gut, a growing skin and wound-repair record, and a defining structural trait — anti-inflammatory action without the pigmentary effect of its parent hormone alpha-MSH ^[4]. We are equally explicit about the gap: there are no published human clinical trials of KPV and no validated human pharmacokinetics ^[1].

We surface the honest limits as prominently as the findings — peptidase lability, the absence of human data, and the difference between marketing claims and what the studies measured ^[1]. Where regulatory status is concerned, we report present-tense, FDA-citable facts only, and we do not assert any future FDA action as a certainty (see our KPV legal status and 503A compounding access page).

Lysine-Proline-Valine: the alpha-MSH(11-13) sequence

Because the compound is named two ways across the literature, we use both: KPV (the single-letter shorthand) and Lysine-Proline-Valine (the full residue name), the sequence H-Lys-Pro-Val-OH at positions 11-13 of alpha-MSH ^[4]. The molecular weight is 342.44 Da and the CAS number is 67727-97-3. Keeping the identity precise is part of the editorial job — it is how a reader confirms that two papers using different names are describing the same molecule ^[4].

What the name means

The "reviews" modifier in this domain is editorial framing — a position we occupy relative to the literature, not a claim about services. We do not review products for sale, offer consultations, or facilitate access to any substance. We read studies and summarize them. For questions about scope or corrections, see our KPV peptide FAQ or reach us through the contact page.